Hypertension is an escalating occupational health concern among information technology (IT) professionals, driven by sedentary behavior, psychosocial stress, and poor lifestyle habits. Despite evidence supporting nurse-led health promotion, its application within corporate settings remains limited. This study aimed to design, implement, and evaluate a nurse-led educational booklet for hypertension prevention among IT professionals in India, with attention to gender-responsive pedagogy.

Methods: A sequential mixed-method design was employed. Phase I involved the development of a culturally tailored hypertension prevention booklet using the Delphi consensus process and Sassen’s Intervention Mapping Framework. Phase II evaluated its impact through a quasi-experimental pre-test/post-test design among 240 IT professionals (aged 25–45 years) in Bengaluru and Hyderabad. The intervention group (n = 120) received the nurse-led booklet program via hybrid workshops and digital reinforcement, while the control group (n = 120) received standard education materials. Outcomes assessed at baseline, 3 months, and 6 months included Knowledge, Attitude, and Practice (KAP) scores, blood pressure (BP), and behavioral indicators. Focus group discussions provided qualitative insights.

Results: The intervention group exhibited a significant improvement in mean KAP scores (57.3 ± 6.1 to 79.4 ± 5.8; p < 0.001) compared to the control group (56.8 ± 6.4 to 59.5 ± 6.7; p = 0.09). Systolic and diastolic BP decreased by 9.4 mmHg and 5.6 mmHg respectively (p < 0.001), accompanied by marked improvements in physical activity and dietary adherence. Thematic analysis revealed that participants valued the booklet’s clarity, visual reinforcement, and relevance to occupational stressors. Gender differences emerged, with female participants demonstrating greater group engagement and males favoring structured feedback mechanisms.