Diarrhea has been one of the most important health problems in developing countries. Diarrhea is characterized by increased frequency of bowel movement, wet stool and abdominal pain. Majority of diarrhea cases are due to bacterial enter pathogens, diarrheagenic Escherichia coli. In developing countries they are the most common causes of morbidity and mortality. The various drug treatments available for diarrhea include the conventional drugs like loperamide, bismuth, subsalicylate and diphenyxolate. Various side effects (abdominal discomfort, dry mouth, nausea, constipation and headache) attributed to these synthetic drugs have stimulated a rapid and continuous growth of interest towards the use of herbal medicine for the treatment of diarrhea. Despite lack of adequate dosing and scarce report of toxicities of medicinal plants, availability and anecdotal report of efficacy have made them important alternative treatment of diarrhea. This review emphasizes on some herbal medicinal plants with their extracts for their anti-diarrhea potential, fifteen extract possessing anti-diarrhea action were sought, the plant decreased the frequency of defecation, reduced the severity of diarrhea in rats, decreased the volume of intestinal fluid accumulation, the distance travelled by charcoal meal in intestinal transit time was also reduced, increased the number of dry faeces, reduced number of wet faeces, decrease in the levels of castor oil-induced diarrhea, enter pooling, and intestinal transit time (anti-motility test), charcoal meal, magnesium sulfate and arachidonic acid-induced diarrhea in animal experimental models were the employed. Accordingly, this review demonstrates the importance of herbal medicine in the treatment of diarrheal thus preventing its further complication.