Background: A physical disability is limitation on a person's physical functioning, dexterity stamina or mobility. A disability is a physical or mental problem that makes it difficult or impossible for a person to walk, see, hear, speak, learn, or do other important things, a physical disability is any type of physical condition that significantly impacts one or more major life activities. The aim of the study: the study aimed to examine the impact of Health Education Program on Caregivers Knowledge, Attitude and Practice toward their Children with Physical Disability in Cheshire Home, Khartoum, Sudan. Material and methods: This is an interventional prospective study, and it involved (113) of Caregivers for disabled children in Cheshire home in Khartoum. Data were collected by a questionnaire and an observational check list. The SPSS computer program was used for data analysis Results: The disabled children age ranged between 1-5 yrs. The care givers were mainly the mothers. Testing the caregivers awareness before intervention showed that only (16.8%) of them were aware of the definition child physical disability. This increased after the training to (97.6%).About (93.8%) of the caregivers didn’t receive any advices or instructions regarding child disability or rehabilitation. Instructions were mainly from the TV, radio, text books or magazines. Before intervention and training practice process, (92.9%) of the disabled children, were taking their meals with entire help, while (9%) of them were taking their food with a little help and (6.2%) were taking their food without any help. However, after intervention and training, about (42.5%) were completely dependent on their cares for feeding.93.8% were not able to interact with others compared to68.1%after intervention. Conclusion: it is necessary to provide the families of disabled children with advice, direction, and provide rehabilitation appliances besides training them how to deal with their disabled children. By that they can overcome and adapt to such problem, and consequently help their disabled children to be independent as much as possible.