Background:Cryptococcus neoformans is an encapsulated yeast and it is most frequent cryptococcal species found in humans. Cryptococcus remains an important opportunistic pathogen among immunocompromised patients. Although there are some reports of Primary cutaneous cryptococcosis. Cryptococcal lesions of skin is a rare feature of disseminated cryptococcosis and has poor outcome if left undiagnosed or treated. We present a case report of 40 years old male on antiretroviral therapy for the past 10 years and CD4 count of 50 cells/ µl. with multiple cutaneous lesions on face, arms and feet which resembled++ to molluscum like cutaneous lesions. Diagnosis of the case was done by India ink preparation of CSF and crushed skin smear from the lesions by gram stain, culture on Sabouraud’s dextrose agar (SDA), Niger seed agar and urease hydrolysis test shown by the organism on Christensen’s urea medium.